London is a heavily populated city and the capital of England. It is also the home of Roger and his wife Anita, as well as Pongo, Perdita and their puppies in the 101 Dalmatians franchise. Various parts of London are shown during the Twilight Bark section as the Dalmatians spread the word about their kidnapped puppies.
It also plays as the primary setting for 101 Dalmatians II: Patch's London Adventure.
However, in the live-action films, the park that Pongo gets the two to meet is St. James Park, after a chase through Trafalgar Square and Oxford Street.
The Second Chance Dogs Home is stationed in London, similar to Battersea Dogs Home in which Cruella's fortune is given to when she is arrested again.
In The Starlight Barking, Sirius gathers the canines together in Trafalgar Square and addresses them from the top of Nelson's column.
London is home to a number of early levels in 102 Dalmatians: Puppies To The Rescue.
Domino and Oddball make their way through Regents Park (helping a squirrel named Fidget and getting Jasper attacked by bees), a toy market (with help from Sgt. Tibbs), Picadilly Circus (trapping Horace down a manhole with help from Fidget), up Big Ben (with help from Yvonne the bat), contacting the "Twilight Bark" (after defeating Cruella at Big Ben), helping Fluffy return some artifacts at the Royal Museum (trapping Le Pelt in the Egyptian exhibit), and pacing through the London underground rail system with help from Chester, a rat hoping to become a stock broker.