The game was based on the 1996 live-action movie 101 Dalmatians rather than the original Disney animated film One Hundred and One Dalmatians, although the character designs were based on the animated film.
The plot features two Dalmatian puppies, Patches (not to be confused with Patch) and Wizzer, and their adventures escaping from captivity in Cruella de Vil's mansion. The game's perspective is from the puppies' point-of-view, called "Puppyvision."
The game play is viewed in a sight known as "Puppyvision," in which you have a clear view of the area Patches and Wizzer may be in at the time.
Since it is a puzzle game, its primary method of controls is to point and click, the highlighter going red whenever a selectable item may appear. There are, however, items that can either help you escape the manor or get the attention of Cruella's henchmen Horace and Jasper (such items would be looking in the library where the other Dalmatians are, or clicking on Patches causing him to bark). If Horace and Jasper hear you and start heading towards you, the Dalmatians must either hide or use a pre-set trap set up by the player; if the player is unable to do so, they will be caught and placed into the billiard room (this does, however, offer a second method to escape the manor).
Once Patches and Wizzer escape the manor, they flee to the mine shaft with Cruella in pursuit. Players must time their throw of the barrels of explosives just right in order to land in another pile of explosives, blasting Cruella from the mine to be arrested by Scotland Yard.
Patches is then awarded with a medal and welcomed into the family as a Dearly Dalmatian.